Animal models play an important role in the investigation of the pathophysiology of retinal degenerations as well as the development of therapies for these conditions. Models range from zebra fish and laboratory rodents to large animals including cats, dogs, pig, sheep, chickens and primates. The models may have spontaneous inherited retinal degenerations or may be engineered models. Electroretinography plays a major role in the study of these models as well as in the assessment of the efficacy of therapeutic interventions. This presentation will briefly describe electroretinographic recording from specific animal models to allow the investigation of retinal dysfunction and give examples of electroretinography used to assess therapeutic outcomes.