Herpes stromal keratitis (HSK) is a chronic immunoinflammatory condition, which develops in response to recurrent corneal infection with herpes simplex virus (HSV). Immune cell influx, neovascularization, loss of corneal sensation, and the stromal opacity in HSV-1 infected cornea are the hallmarks of HSK. In United States, HSK is a major cause of infection-induced blindness and the current treatments involve long-term use of anti-virals and the topical application of corticosteroids. Considering the importance of immune cell influx in the development of HSK, the focus of this presentation will be to highlight the novel role of neutrophils and altered cellular metabolism in pathogenesis of HSK.