The spectrum of ocular immunpathologies include a wide range of conditions that encompass both the globe as well as adnexal structures (e.g. lacrimal gland and eyelids) that provide critical support for the functioning of the eye and visual system. These conditions include the various ocular atopic (allergic) disorders, dry eye disease, immune-mediated glaucoma syndromes, various uveitic disorders and some retinopathies, among others. This introductory lecture will provide the audience with a high-level overview of ocular immune mediated disorders and describe the areas of highest unmet medical need and relevant therapeutic strategies.