In my presentation I will discuss the development of the Save Sight Registries, which provide uniquely high quality data by tracking internationally agreed minimum, patient-centered treatment outcome sets with mandatory fields. The flagship module, Fight Retinal Blindness!, has tracked outcomes of intravitreal injections for 15 years. Issues we have addressed include privacy, user engagement and issues associated with analysis of ophthalmic real world data. Greater global consensus on the standard minimum data to collect for treatment outcomes of ophthalmic diseases would add value to analyses. Development in this field will include interoperability with other clinical and imaging datasets for seamless transfer of high quality clinical data for analysis and AI-driven insights from these large datasets.